Diabetes has become one of the most prominent chronic diseases in many of the world’s populations. Whilst type 1 is genetic in origin, type 2 is primarily a lifestyle disease. Diabetes and the associated hyperglycaemia (high blood glucose) is related to an increase in the production of free radicals by a process called glycation. In essence, it is a process whereby the elevated blood glucose binds to proteins, in turn creating free radicals. The free radicals produced by glycation can be up to 50 times higher than normal and are implicated in ageing and tissue damage.
Additionally, both type 1 and 2 diabetes are associated with low glutathione. [1-9] The resulting oxidative stress and depletion of the cellular antioxidant defense system contributes to the progress of coronary artery disease. This plays a major role in the development of diabetes and its ongoing complications.
Glutathione in its role as a free radical scavenger has been shown to drastically reduce the occurrence and duration of oxidative stress. Enhancing cellular glutathione is therefore of paramount importance in managing diabetes and reducing negative medical outcomes.
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- Pastore, A., et al., All glutathione forms are depleted in blood of obese and type 1 diabetic children. Pediatric Diabetes, 2012. 13(3): p. 272-277.
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