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Glutathione is one of the most studied molecules in healthcare. More than 80,000 papers on glutathione published in peer reviewed scientific journals attest to the importance of this peptide in health and wellness.

The content on this website has been selected to educate healthcare practitioners and others with a deep interest in maintaining good health. By its very nature, the subject is highly technical and though an attempt has been made to simplify the content matter…

Glutathione (GSH) is often termed the “master antioxidant”.  This tripeptide is ubiquitous in nature and is produced by every organism from bacteria, to plants to animals that derives energy from oxidative phosphorylation and respiration.  Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue...
Glutathione, often referred to as the “Master Antioxidant”, is the most biologically abundant antioxidant that protects almost all aerobic (air breathing) organisms from bacteria to humans. It is found mainly intracellularly (inside cells) where its concentration is in the same order as that other vital nutrient, glucose. There is no doubt that glutathione is of utmost importance for the human body. In fact, it plays a vital...
Glutathione (GSH) is synthesized in the cytoplasm in virtually all cells from its constituent amino acids by two sequential ATP-requiring enzyme catalyzed reactions (see figure below) . The first reaction is the formation of the dipeptide γ-glutamylcysteine (GGC) from the amino acids L-glutamic acid and L-cysteine. The second reaction adds a glycine to the Gamma-glutamylcysteine to produce the tripeptide glutathione. The first reaction is...
Gamma-glutamylcysteine (GGC) is a dipeptide and is the immediate precursor to the tripeptide glutathione (GSH). The intracellular concentration of gamma-glutamylcysteine (GGC) is generally low because gamma-glutamylcysteine (GGC) reacts rapidly with glycine to form glutathione (GSH). This second and final reaction step in glutathione biosynthesis is catalyzed by the activity of the ATP dependent glutathione synthase (GS) enzyme. Gamma-glutamylcysteine (GGC) is essential to mammalian life....
Oxidative stress is considered a main player in kidney disease and associated mortality rates. This sustained production of free radicals is in...
Cardiovascular disease (CDV) is the number 1 cause of death globally, taking an estimated 18 million lives each year. Whilst an increased...
Globally, infertility is a major health problem and can cause significant financial and psychological stress. In many cases, the cause of infertility...
Diabetes has become one of the most prominent chronic diseases in many of the world’s populations. Whilst type 1 is genetic in...
There is an on-going proliferation of alternative delivery systems for Glutathione (GSH) in the misguided attempt that one may be effective. This...
By William Sears, MD After more than 50 years of practice, by far two of the most difficult concepts...
Gamma-glutamylcysteine, (GGC) is a naturally occurring dipeptide found in all mammalian life and is a key intermediate in the gamma (γ) -glutamyl...
Given that a vaccine for COVID-19 is quite possibly a long way off, it is more important than ever to explore other...

Popular posts

Gamma-Glutamylcysteine increases cellular glutathione

Gamma-glutamylcysteine, (GGC) is a naturally occurring dipeptide found in all mammalian life and is a key intermediate in the gamma (γ) -glutamyl...

Glutathione and it’s importance to Life

Glutathione, often referred to as the “Master Antioxidant”, is the most biologically abundant antioxidant that protects almost all aerobic (air breathing) organisms...

Glutathione and Gastrointestinal Disease

The extensive surface area of our digestive system enables us to extract all of the essential nutrients from our diet. The intestinal...

Raising cellular Glutathione levels with Gamma-Glutamylcysteine

A human clinical trial demonstrated that oral Gamma-glutamylcysteine (GGC) is directly taken up by cells and increases glutathione (GSH) within several hours....

How a physician explains antioxidants to patients

By William Sears, MD After more than 50 years of practice, by far two of the most difficult concepts...

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